Treatment of Primary Sjögren Syndrome

Treatment of primary Sjögren syndrome with rituximab: a randomized trial.

BACKGROUND Primary Sjögren syndrome (pSS) is an autoimmune disorder characterized by ocular and oral dryness or systemic manifestations. OBJECTIVE To evaluate efficacy and harms of rituximab in adults with recent-onset or systemic pSS. DESIGN Randomized, placebo-controlled, parallel-group trial conducted between March 2008 and January 2011. Study personnel (except pharmacists), investigator...

Treatment of primary Sjögren syndrome: a systematic review.

CONTEXT A variety of topical and systemic drugs are available to treat primary Sjögren syndrome, although no evidence-based therapeutic guidelines are currently available. OBJECTIVE To summarize evidence on primary Sjögren syndrome drug therapy from randomized controlled trials. DATA SOURCES We searched MEDLINE and EMBASE for articles on drug therapy for primary Sjögren syndrome published b...

Orbital Myositis and Primary Sjögren Syndrome.

Neurological involvement in Primary Sjögren Syndrome.

OBJECTIVES To perform an observational retrospective cross-sectional case-control study to evaluate prevalence, clinical patterns and outcomes of neurological involvement in a cohort of Primary Sjögren Syndrome (pSS) patients followed up in a single center. MATERIAL AND METHODS From a total of 93 pSS patients, diagnosed according to the 2002 criteria proposed by the American-European Consensu...

Primary Sjögren Syndrome in Han Chinese

The epidemiological characteristics of Sjögren syndrome (SS) are significantly varied in different countries. We conducted the present study to survey the epidemiological characteristics of primary SS in China. We recruited 483 primary SS patients from 16 Chinese medical centers nationwide from January 2009 to November 2011 and assessed salivary and lacrimal gland dysfunction, organ involvement...